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Serum UDCA was measured every three months for two years in the large, multicentre, prospective, placebo-controlled Canadian trial of UDCA in 224 patients with Primary Biliary Cirrhosis.

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S-adenosyl-L-methionine in the treatment of patients with intrahepatic cholestasis of pregnancy: a randomized, double-blind, placebo-controlled study with negative results.

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Se debería tomar URSOFALK sólo después de consultar al médico: en caso de vesícula biliar no representable radiológicamente, cálculos biliares calcificados, contractilidad alterada de la vesícula biliar, cólicos biliares frecuentes, estadio avanzado de la cirrosis biliar primaria, ya que en él no es seguro el provecho terapéutico.

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Treatment failure, the main efficacy end point measured during this study, was defined as death, need for liver transplantation, histologic progression by two stages or to cirrhosis, development of varices, ascites or encephalopathy, marked worsening of fatigue or pruritus, inability to tolerate the drug, doubling of serum bilirubin and voluntary withdrawal.

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Total parenteral nutritionassociated intrahepatic cholestasis in infants: 25 years' experience.

In combination with hormonal replacement therapy (HRT): Dydrogesterone prevents thickening of the uterine lining in the patient taking HRT.

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Gallbladder fasting volume and ejection fraction did not change at the end of gallstone dissolution treatment in radiolucent gallstone patients.

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Information on adverse events (AEs) was obtained during patient contacts by telephone at 1 and 3 months, and prior to post-intervention duodenoscopy at 6 months.

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Twenty-four patients entered the trial; eight had deliveries before 2 weeks of treatment and one dropped out.

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Shekels LL, Beste JE, Ho SB: Tauroursodeoxycholic acid protects in vitro models of human colonic cancer cells from cytotoxic effects of hydrophobic bile acids.

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In general, other symptoms of overdose are unlikely because the absorption of ursodeoxycholic acid decreases with increasing dose and therefore more is excreted with the faeces.

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Absolute exclusion criteria included all non-PN causes of cholestasis.

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Pre-defined secondary endpoints were: (1) gallstone complications, (2) episodes of non-severe right upper quadrant or midline epigastric pain, (3) (non-prescription) analgesics taken for biliary pain.

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