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These drugs are toxic to the body and could have repercussions down the line that we have no idea about because they have only been used since about 2000.
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In adult non-tumor and tumor-bearing female animals, letrozole is as effective as ovariectomy in reducing uterine weight, elevating serum LH, and causing the regression of estrogen-dependent tumors.
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Based on 62 months median duration of follow-up in the randomized Letrozole arm in the Safety population the incidence of cardiovascular disease at any time after randomization was 14.
The incidence of adverse reactions was similar for Femara and tamoxifen.
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The matter is that a manufacturer can not possess a patent for a certain chemical agent, this is why different manufacturers of generic drugs are able to produce the so-called generics legally.
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My oncologist confirmed that is definitely a Letrozole side effect.
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If we use up all the treatment options in trying to prevent recurrence we may be deprived of very effective and useful therapies in the event of that recurrence occurring.
They suggest you Phase off the program at least 2 weeks before drinking alcohol.
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PR status wasn't important, it's the estrogen that's important and predicts your response to the AIs, and information on the internet that talked about a worse response to AIs for this type of cancer.
General side effects have included asthenia (22.
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Trials of AIs in the adjuvant setting (given to prevent relapse after surgery for breast cancer) show that they are associated with a better disease-free survival than tamoxifen, but few conventionally-analyzed clinicals trials have shown that AIs have an overall survival advantage compared with tamoxifen, and there is no good evidence they are better tolerated.
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It was believed that one would find a bi-directional relationship between insomnia and pain, but instead it was found that trouble sleeping was more likely a cause, rather than a consequence, of pain in patients with cancer.
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Femara is usually not compared to a placebo ("sugar pill").
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It works closely together with vitamin D and minerals to build and maintain our bones.
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In contrast to ovariectomy, treatment with letrozole does not lead to an increase in serum FSH.
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I'm a survivor, I had a masectomy in 1995, took for 5 years, then went into a double blind study for femara, after a year, because of the great results, the study was stopped, it turned out I was taking a placebo not femara, but then I started on femara, that was about 2003.
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