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This harm could not be assessed in trials that enrolled patients with chronic myeloid leukemia because acute leukemia was evaluated as an outcome rather than as a medication-related toxicity.

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The contribution of cyclooxygenase-1 and -2 to persistent thromboxane biosynthesis in aspirin-treated essential thrombocythemia: implications for antiplatelet therapy.

Interferon α therapy for patients with essential thrombocythemia.

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Moreover, ingestion of diluted natural honey showed reduction effect on concentrations of prostaglandins such as PGE 2, PGF 2α and thromboxane B 2 in plasma of normal individuals ()).

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Ex vivo studies of mononuclear cells taken from patients on hydroxyurea did not demonstrate increased genomic instability that might contribute to teratogenesis or leukemogenesis.

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